Abstract
Five known kaurane type diterpenoids, 16αH,17-isovaleryloxy-ent-kauran-19-oic acid (1), 16α-hydroxy-17-isovaleryloxy-ent-kauran-19-oic acid (2), paniculoside-IV (3), 16α-hydroxy-ent-kau-ran-19-oic acid (4), andent-kaur-16-en-19-oic acid (5) were isolated from the root ofAcanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. The structures of these compounds were established from physicochemical and spectral data. Among the isolated compounds 16αH,17-isovaleryloxy-ent-kauran-19-oic acid (1) showed potent inhibitory activity (IC50 value, 16.2 uM) on TNF-α secretion from HMC-1, a trypsin-stimulated human leukemic mast cell line.
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Cai, X.F., Shen, G., Dat, N.T. et al. Inhibitory effect of kaurane type diterpenoids fromAcanthopanax koreanum on TNF-α secretion from trypsin-stimulated HMC-1 cells. Arch Pharm Res 26, 731–734 (2003). https://doi.org/10.1007/BF02976683
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DOI: https://doi.org/10.1007/BF02976683