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Platelet anti-aggregatory effects of coumarins from the roots ofAngelica genuflexa andA. gigas


Five coumarins, isoimperatorin (1), pabulenol (2), isooxypeucedanin (3), oxypeucedanin hydrate (4) and osthol (5) were isolated from the MeOH extract ofAngelica genuflexa in the course of searching for anti-platelet and anti-coagulant components from plants. Pabulenol (2) was isolated fromA. genuflexa for the first time. The five compounds isolated fromA. genuflexa, together with decursinol angelate (6), decursin (7) and nodakenin (8) fromA. gigas were evaluated for their effects on platelet aggregation and blood coagulation. Compounds 2, 5, 6 and 7 were observed to be either equally effective or 2~4 times more inhibitory than ASA in both arachidonic acid and U46619 (TXA2 mimetic) induced platelet aggregations.

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Correspondence to Hye Sook Yun-Choi.

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Lee, Y.Y., Lee, S., Jin, J.L. et al. Platelet anti-aggregatory effects of coumarins from the roots ofAngelica genuflexa andA. gigas . Arch Pharm Res 26, 723–726 (2003).

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