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Inhibitory effects of luteolin isolated fromixeris sonchifolia hance on the proliferation of hepg2 human hepatocellular carcinoma cells

Archives of Pharmacal Research volume 26, pages 151–156 (2003)Cite this article

Abstract

We investigated the anti-proliferative effects of luteolin and apigenin, isolated fromIxeris sonchifolia Hance, on HepG2 human hepatocellular carcinoma cells. In MTT assay luteolin showed more efficient anti-proliferative effects on cells than apigenin did. According to propidium iodide staining and flow cytometry studies, we postulated that these effects might be a result of cell cycle arrest. Hence we examined the changes of protein expressions related to cell cycle arrest. Western blotting data demonstrated that the down-regulated expression of CDK4 was correlated to the increase of p53 and CDK inhibitor p2-1WAF1/cIp1 protein. These data suggest that luteolin may have potential as an anti-cancer agent.

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Authors and Affiliations

  1. Department of Pharmacy, Pusan National University, 609-735, Busan

    Yee Su Bog, Lee Jung Hwa, Chung Hae Young, Im Kwang Sik & Kim Nam Deuk

  2. Department of Food and Nutrition, Silla University, 617-736, Busan

    Bae Song Ja

  3. Faculty of Food Science and Biotechnology, Pukyong National University, 608-737, Busan, Korea

    Choi Jae Soo

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  1. Yee Su Bog
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  2. Lee Jung Hwa
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  3. Chung Hae Young
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  4. Im Kwang Sik
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  6. Choi Jae Soo
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Correspondence to Kim Nam Deuk.

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Su Bog, Y., Jung Hwa, L., Hae Young, C. et al. Inhibitory effects of luteolin isolated fromixeris sonchifolia hance on the proliferation of hepg2 human hepatocellular carcinoma cells. Arch Pharm Res 26, 151–156 (2003). https://doi.org/10.1007/BF02976662

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  • DOI: https://doi.org/10.1007/BF02976662

Key words

  • Luteolin
  • Apigenin
  • Ixeris sonchifolia H.
  • HepG2 cells
  • Cell cycle arrest