Inhibitory effects of luteolin isolated fromixeris sonchifolia hance on the proliferation of hepg2 human hepatocellular carcinoma cells

Abstract

We investigated the anti-proliferative effects of luteolin and apigenin, isolated fromIxeris sonchifolia Hance, on HepG2 human hepatocellular carcinoma cells. In MTT assay luteolin showed more efficient anti-proliferative effects on cells than apigenin did. According to propidium iodide staining and flow cytometry studies, we postulated that these effects might be a result of cell cycle arrest. Hence we examined the changes of protein expressions related to cell cycle arrest. Western blotting data demonstrated that the down-regulated expression of CDK4 was correlated to the increase of p53 and CDK inhibitor p2-1WAF1/cIp1 protein. These data suggest that luteolin may have potential as an anti-cancer agent.

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Correspondence to Yee Su Bog or Lee Jung Hwa or Chung Hae Young or Im Kwang Sik or Bae Song Ja or Choi Jae Soo or Kim Nam Deuk.

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Su Bog, Y., Jung Hwa, L., Hae Young, C. et al. Inhibitory effects of luteolin isolated fromixeris sonchifolia hance on the proliferation of hepg2 human hepatocellular carcinoma cells. Arch Pharm Res 26, 151 (2003). https://doi.org/10.1007/BF02976662

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Key words

  • Luteolin
  • Apigenin
  • Ixeris sonchifolia H.
  • HepG2 cells
  • Cell cycle arrest