Abstract
The aim of this study was to gain information on the effects of the crystal form of corticosteroids on the topical anti-inflammatory activity. Two different crystal forms, Form A and Form B, of the drugs of prednicarbate, hydrocortisone, betamethasone 17-valerate, prednisolone, and methyl prednisolone were prepared and their topical anti-inflammatory activities were measured using arachidonic acid induced ear edema assay in mice. Two crystal forms of the drugs showed differences in anti-inflammatory activity. Among the drugs examined, Form B of prednicarbate and betamethasone 17-valerate showed significantly more potent anti-inflammatory activities as compared to their Form A.
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Sohn, YT., Kim, SY. Effect of crystal form onin vivo topical anti-inflammatory activity of corticosteroids. Arch Pharm Res 25, 556–559 (2002). https://doi.org/10.1007/BF02976618
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DOI: https://doi.org/10.1007/BF02976618