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The effect of storage conditions on the permeability of porcine buccal mucosa

Archives of Pharmacal Research volume 25, Article number: 546 (2002) Cite this article

An Erratum to this article was published on 01 March 2003

Abstract

The impact of storage conditions on the permeability of porcine buccal mucosa to [3H]water and [14C]mannitol was assessed. The fresh pocine buccal tissue (fresh tissue) was obtained by utilizing pig heads within 24 hours of slaughter. The stored and frozen porcine buccal tissues (stored tissue and frozen tissue) were obtained after the storage of the tissue intact in the pig heads at 4°C or -20°C, respectively, for 24 h. The results demonstrated that the barrier properties of the porcine buccal mucosa were maintained with regard to [3H]water permeability when stored at 4°C for 24 h. However, freezing the tissue resulted in tissue damage illustrated by a significant increase in [3H]water permeability. [14C]Mannitol does not appear to be a suitable model solute to assess the ex vivo permeability of porcine buccal mucosa due to its extremely low permeability.

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Authors and Affiliations

  1. Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmacal Sciences, Purdue University, 47907-1336, West Lafayette, IN, USA

    Jaehwi Lee

  2. College of Pharmacy, Chung-Ang University, 156-756, Seoul, Korea

    Sang Kil Lww & Young Wook Choi

Authors
  1. Jaehwi Lee
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  2. Sang Kil Lww
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  3. Young Wook Choi
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Correspondence to Jaehwi Lee.

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An erratum to this article is available at http://dx.doi.org/10.1007/BF02976838.

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Lee, J., Lww, S.K. & Choi, Y.W. The effect of storage conditions on the permeability of porcine buccal mucosa. Arch Pharm Res 25, 546 (2002). https://doi.org/10.1007/BF02976616

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  • DOI: https://doi.org/10.1007/BF02976616

Key words

  • Buccal permeability
  • Porcine buccal mucosa
  • Storage
  • Freezing
  • Water
  • Mannitol