Skip to main content
SpringerLink
Log in

Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root ofSalvia miltiorrhiza

  • Research Articles
  • Articles
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

The inhibitory activity of tanshinones fromSalvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15, 16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 μg/ml and 11.1 μg/ml. However, tanshinone HA (2) and tanshinone I (4) showed very weak inhibition (IC50 value: > 250 μg/ml). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Cases S, Smith S, Zheng Y, Myers H, Lear SR., Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese Jr RV. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.Proc. Natl. Acad. Sci. USA, 95, 13018–13023 (1998).

    Article  PubMed  CAS  Google Scholar 

  • Chang, H., and But, P. (Eds). Pharmacology and Applications of Chinese Materia Medica; World Scientific Publishing Co., Singapore, pp. 255–268 (1986).

    Google Scholar 

  • Coleman RA. Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine.Methods Enzymol., 209, 98–103 (1992).

    Article  PubMed  CAS  Google Scholar 

  • Gray GA, Tartaglia LA. Medicinal strategies in the treatment of obesity.Curr. Opin. Lipidol., 11, 229–234 (2000).

    Article  Google Scholar 

  • Lehner R., Kuksis A.. Biosynthesis of triacylglycerols.Prog. Lipid Res., 35, 169–201 (1996).

    Article  PubMed  CAS  Google Scholar 

  • Ryu, S. Y., Lee, C. O., and Choi, S. U., In vitro cytotoxicity of tanshinones fromSalvia miltiorrhiza.Planta Med., 63, 339–342 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow Bryan, Sanan DA, Rober J, Eckel RH, Farese Jr RV. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.Nat. Genet., 25, 87–90 (2000).

    Article  PubMed  CAS  Google Scholar 

  • Tabata N., Ito M., Tomoda H., Omura S. Xanthohumols, diacylglycerol acyltransferase inhibitors, fromHumulus lupulus.Phytochemistry, 46, 683–687 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Tomoda H., Ohyama Y., Abe T., Tabata N., Namikoshi M., Yamaguchi Y., Masuma R., Omura S. Roselipines, inhibitors of diacylglycerol acyltransferase, produced byGliocalidum roseum KF-1040.J. Antibiotics, 52, 689–694 (1999).

    CAS  Google Scholar 

  • Tomoda H., Ito M., Tabata N., Masuma R., Yamaguchi Y., Omura S. Amidepsines, inhibitors of diacylglycerol acyltransferase produced byHumicola sp. FO-2942.J. Antibiotics, 48, 937–941 (1995).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, P. O. Box 115, 305-600, Yusong, Taejon, Korea

    Jeong Suk Ko, Mi Yeon Chung, Mun-Chual Rho, Hyun Sun Lee & Young Kook Kim

  2. Korea Research Institute of Chemical Technology, Yusong, P. O. Box 107, 305-600, Taejon, Korea

    Shi Young Ryu & Young Sup Kim

  3. College of Pharmacy, Chungnam National University, 305-764, Taejon, Korea

    Jong Seong Kang

Authors
  1. Jeong Suk Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shi Young Ryu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Young Sup Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mi Yeon Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jong Seong Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mun-Chual Rho
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hyun Sun Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Young Kook Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hyun Sun Lee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ko, J.S., Ryu, S.Y., Kim, Y.S. et al. Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root ofSalvia miltiorrhiza . Arch Pharm Res 25, 446–448 (2002). https://doi.org/10.1007/BF02976599

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02976599

Key words

Search

Navigation