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Recognition of the importance of imidazolidinone motif for cytotoxicity of 4-phenyl-1-arylsulfonylimidazolidinones using thiadiazolidine-1,1 -dioxide analogs

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Abstract

For probing the importance of planarity of imidazolidinone motif of 4-phenyl-1-(N-acylindoline-5-sulfonyl)imidazolidinones1 for their cytotoxicity, 4-phenyl-1-(N-acylindoline-5-sulfonyl)[1,2,5]thiadiazolidine-1,1-dioxides2 were prepared and their cytotoxicity were measured against human lung carcinoma (A549), human colon carcinoma (COLO205), human ovarian cancer (SK-OV-3), human leukemic cancer (K562), and murine colon adenocarcinoma (Colon26) cell linesin vitro. Although only carbonyl moiety of imidazolidinone ring was replaced with sulfonyl group, compounds2 do not show any activity against all five cancer cell lines unlike 1. Therefore the planarity of imidazolidinone ring of1 should be an important factor for their cytotoxic activity.

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  1. College of Pharmacy, Chungnam National University, 305-764, Daejeon, Korea

    II-Whan Kim & Sang-Hun Jung

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  1. II-Whan Kim
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  2. Sang-Hun Jung
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Correspondence to Sang-Hun Jung.

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Kim, IW., Jung, SH. Recognition of the importance of imidazolidinone motif for cytotoxicity of 4-phenyl-1-arylsulfonylimidazolidinones using thiadiazolidine-1,1 -dioxide analogs. Arch Pharm Res 25, 421–427 (2002). https://doi.org/10.1007/BF02976594

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  • DOI: https://doi.org/10.1007/BF02976594

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