Summary
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1.
A clinical case of osteomalacia secondary to idiopathic steatorrhoea was found to exhibit the biochemical features of renal tubular acidosis.
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2.
Treatment with vitamin D resulted in reversal of systemic acidosis with restoration to normal of renal tubular acidifying power.
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3.
It is suggested that vitamin D is necessary for renal tubular (and perhaps gastro-intestinal) transport of hydrogen and phosphate ions. Evidence from the literature is quoted in favour of the further concept that transport of phosphate, hydrogen ion, glucose and amino-acids may be vitamin D dependent.
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Muldowney, F.P., Freaney, R. & Brennan, P. A case of osteomalacia and renal tubular acidosis associated with occult idiopathic steatorrhoea; the effect of vitamin d on renal tubular hydrion transport. Ir. J. Med. Sc. 40, 435–448 (1965). https://doi.org/10.1007/BF02976590
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DOI: https://doi.org/10.1007/BF02976590