Abstract
The total synthesis of a demethoxy-egonol isolated fromStyrax obassia, 5-(3-hydroxypropyl)-2-(3′,4′-methylenedioxyphenyl)benzofuran (9), is described. The key steps involve the construction of a 2-arylbenzofuran skeleton7 from methyl 3-(4-hydroxyphenyl)propionate with 2-chloro-2-methylthio-(3′,4′-methylenedioxy)acetophenone (6) in the presence of ZnCl2 and successive desulfurization of the resulting product7.
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Choi, H.D., Ha, M.C., Seo, P.J. et al. Total synthesis of a demethoxy-egonol fromStyrax obassia . Arch Pharm Res 23, 438–440 (2000). https://doi.org/10.1007/BF02976567
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DOI: https://doi.org/10.1007/BF02976567