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Cytotoxicity of two novel cisplatin analogues, (CPA)2Pt[DOLYM] and (DACH)Pt[DOLYM], to human cancer cellsin vitro

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Abstract

Despite the impressive antitumor activity of cisplatin, two major limitations of the drug, that is severe side effects and drug-resistance of cancer cells, make its use difficult for cancer therapy. These limitations have resulted in a great deal of effort having been expended into structural modifications of cisplatin. In this study, we tested two novel cisplatin analogues, (CPA)2Pt [DOLYM] (COMP-I) and (DACH)Pt[DOLYM] (COMP-II), for the mode of cytotoxic action against human tumor cells comparing with cisplatin and carboplatinin vitro. These two novel analogues had considerable cytotoxic activities against five kinds of human solid tumor cells, and especially COMP-II was more effective on HCT15 colon cancer cells than other compounds. In addition, COMP-II had cytostatic activity at low concentrations (10≈0.3 μg/ml), but other compounds revealed little effect on tumor growth at the low concentration.

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Authors and Affiliations

  1. Pharmaceutical Screening Lab., Korea Research Institute of Chemical Technology, Daedeog-Danji, Yusong, P.O. Box 107, 305-600, Taejeon, Korea

    Sang-Un Choi, Kwang-Hee Kim, Eun-Jung Choi, Sung-Hee Park & Chong-Ock Lee

  2. Inorganic Chemistry Lab., Korea Institute of Science and Technology, 130-650, Seoul, Korea

    Kwan-Mook Kim & Youn-Soo Shon

  3. Cheongyang, P.O. Box 131, 130-650, Seoul, Korea

    Kwan-Mook Kim & Youn-Soo Shon

Authors
  1. Sang-Un Choi
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  2. Kwang-Hee Kim
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  3. Eun-Jung Choi
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  4. Sung-Hee Park
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  5. Kwan-Mook Kim
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  6. Youn-Soo Shon
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  7. Chong-Ock Lee
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Choi, SU., Kim, KH., Choi, EJ. et al. Cytotoxicity of two novel cisplatin analogues, (CPA)2Pt[DOLYM] and (DACH)Pt[DOLYM], to human cancer cellsin vitro . Arch Pharm Res 22, 151–156 (1999). https://doi.org/10.1007/BF02976539

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  • DOI: https://doi.org/10.1007/BF02976539

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