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Effect of biphenyl dimethyl dicarboxylate on the humoral immunosuppression by ketoconazole in mice

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  • Microbiology & Immunology
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Abstract

The present study was undertaken to investigate the effect of biphenyl dimethyl dicarboxylate (PMC) on the humoral immunosuppression by ketoconazole (KCZ) in ICR mice. PMC at a dose of 6 mg/kg was administered orally to mice daily for 14 consecutive days. KCZ was suspended in RPMI 1640 medium and orally administered at 160 mg/kg/day 2 hrs after the adminstration of PMC. Mice were immunized and challenged with sheep red blood cells (SRBC). The results of the present study are summarized as follows; a gain of body weight and relative weights of spleen and liver were significantly increased by combination of PMC and KCZ, as compared with those in mice treated with KCZ alone. Splenic plaque forming cells (PFC) and hemagglutination (HA) titers to SRBC were greatly enhanced by the combination of PMC and KCZ, compared with treatment of KCZ alone. The elevation of serum glutamicpyruvic transaminase (S-GPT) and total protein levels caused by KCZ were reduced to normal level by the combination of PMC and KCZ. In addition, lower serum albumin and A/G ratio were also increased to normal level. These findings indicate that PMC has a protective effect against KCZ-induced humoral immunosuppression.

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Authors and Affiliations

  1. Department of Physical Therapy, College of Natural Science, Dongshin University, Naju, 520-714, Chunam, Korea

    Joung Hoon Kim

  2. College of Pharmacy, Woosuk University, 565-800, Samrae-up, Korea

    Jong Pil Lim & Tae Wook Kang

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  1. Joung Hoon Kim
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Kim, J.H., Lim, J.P. & Kang, T.W. Effect of biphenyl dimethyl dicarboxylate on the humoral immunosuppression by ketoconazole in mice. Arch Pharm Res 22, 124–129 (1999). https://doi.org/10.1007/BF02976535

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  • DOI: https://doi.org/10.1007/BF02976535

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