Abstract
Poly(ethylene glycol)(PEG) macromers terminated with acrylate groups and semi-interpenetrating polymer networks (IPNs) composed of poly-ε-caprolactone(PCL) and PEG macromer were synthesized with the aim of obtaining a bioerodible hydrogel that could be used to release drugs for implantable delivery system. Polymerization of PEG macromer resulted in the formation of cross-linked gels due to the multifunctionality of macromer. Non-crosslinked PCL chains were interpenetrated into the cross-linked three-dimensions networks of PEG. The release of 5-fluorouracil(5-FU) from the IPNs increased with increasing PEG contents in the IPNs, large drug loading, lower concentration of PEG macromer in the IPNs concentration and the higher molecular weight of PEG macromer. Also, 5-FU was more fast released than hydrocortisone to the increased water solubility.
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Kim, SH., Ha, JH., Jung, YJ. et al. Drug release from bioerodible hydrogels composed of poly-ε-caprolactone/poly(ethylene glycol) macromer semiinterpenetrating polymer networks. Arch. Pharm. Res. 18, 18–21 (1995). https://doi.org/10.1007/BF02976501
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DOI: https://doi.org/10.1007/BF02976501