Abstract
The accelerated stability of dimethoxy biphenyl monocarboxylate·HCl (DDB-S) was investigated in 6 mg/mL water solution in the pH ranging 2–10 and the temperature of 45–85°C. The observed rate of degradation followed first-order kinetics. The energy of activation for DDB-S degradation was calculated to be 14.1 and 16.5 Kcal/mole at pH 5 and in distilled water, respectively. The degradation rate constant (K25°C) obtained by trending line analysis of Arrhenius plots for DDB-S was 5.3×10−6 h−1. The times to degrade 10% (t10) and 50% (t50) at 25°C were 829 and 5,416 days, respectively DDB-S exhibited the fastest degradation at pH 10 and the slowest rate at pH 5. In addition, at 65°C, degradation rate constants of DDB-S were 0.066, 0.059, 5.460, 32.171, and 1.41×10−6 h−1 at pH 2, 5, 8, 10 and in distilled water, respectively. These observations indicated that the rate-pH profile of DDB-S showedgeneral acid-base catalysis reaction in the range of pH 2–10.
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Choi, WC., Kim, DD., Shin, YH. et al. Influence of temperature and pH on the stability of dimethoxy biphenyl monocarboxylate·HCl solutions. Arch. Pharm. Res. 24, 159–163 (2001). https://doi.org/10.1007/BF02976484
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DOI: https://doi.org/10.1007/BF02976484