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Synthesis andin vitro antibacterial activity of cephalosporins with a pyridinium substituent carrying an isoxazole moiety at the C-3 position

Archives of Pharmacal Research volume 24, pages 89–94 (2001)Cite this article

Abstract

Several quaternary pyridinium cephalosporin analogues were prepared and evaluatedin vitro for antibacterial activity against selected Gram-positive and Cram-negative organisms. Most of the synthesized analogues were either as effective or less effective against the tested bacterial organisms than the reference compounds, Cefpirome and Ceftazidime.

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Affiliations

  1. Department of Medicinal Chemistry, Dong-A Pharm. Co. Ltd., 47-5, Sanggal-ri, Kiheung-up, 449-900, Yongin-si, Kyunggi-do, Korea

    Sunghak Choi, Jaekeol Rhee & Minsun Chang

  2. College of Pharmacy, Kangwon National University, 200-701, Chunchon, Kangwon, Korea

    Haeil Park, Hyunjoo Choi & Jinhee Jang

Authors
  1. Haeil Park
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  2. Hyunjoo Choi
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  3. Jinhee Jang
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  4. Sunghak Choi
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  5. Jaekeol Rhee
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  6. Minsun Chang
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Correspondence to Haeil Park.

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Park, H., Choi, H., Jang, J. et al. Synthesis andin vitro antibacterial activity of cephalosporins with a pyridinium substituent carrying an isoxazole moiety at the C-3 position. Arch. Pharm. Res. 24, 89–94 (2001). https://doi.org/10.1007/BF02976473

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  • DOI: https://doi.org/10.1007/BF02976473

Key words

  • Quaternary pyridinium cephalosporin
  • Isoxazole moiety
  • Anti-staphylococcal activity
  • Anti-pseudomonal activity