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Inhibitory effects of crude drugs on α-glucosidase

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Abstract

The inhibitory activity of several crude drugs on α-glucosidases, which are the key enzymes for carbohydrate digestion and the prevention of diabetic complications, was investigated. Several crude drugs including Terminaliae Fructus, Mori Cortex Radicis, Caesalpiniae Lignum andGyrophora esculenta potently inhibited maltase and sucrase isolated from rat intestine, while Arecae Semen and Corni Fructus remarkably inhibited α-amylase. Caesalpiniae Lignum andGyrophora esculenta exhibited significant reductions of blood glucose elevation in mice loaded with maltose and sucrose.

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Authors and Affiliations

  1. East West Medical Research Institute, Kyung-Hee University, 1 Hoegi, Dongdaemun-ku, 130-701, Seoul, Korea

    Hyuck-Jai Choi & Nam Jae Kim

  2. Department of Microbiology, College of Pharmacy, Kyung-Hee University, 1, Hoegi, Dongdaemun-ku, 130-701, Seoul, Korea

    Dong-Hyun Kim

Authors
  1. Hyuck-Jai Choi
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  2. Nam Jae Kim
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  3. Dong-Hyun Kim
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Correspondence to Dong-Hyun Kim.

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Choi, HJ., Kim, N.J. & Kim, DH. Inhibitory effects of crude drugs on α-glucosidase. Arch Pharm Res 23, 261–266 (2000). https://doi.org/10.1007/BF02976457

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  • DOI: https://doi.org/10.1007/BF02976457

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