Abstract
The immunomodulating activity of a polysaccharide isolated fromMorus alba (PMA) root bark was examined in murine splenic lymphocytes. PMA enhanced proliferation of splenic lymphocytes in a synergistic manner in the presence of mitogens. However, PMA suppressed primary IgM antibody production, from B cells, which was activated with lipopolysaccharide, a polyclonal activator, or immunized with a T-cell dependent antigen sheep red blood cells. Our observations showed that the immunomodulating activity of PMA increased lymphocyte proliferation and that PMA decreased antibody production from B cells, which was distinct from those of other plant-originated polysaccharides.
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Kim, H.M., Han, S.B., Lee, K.H. et al. Immunomodulating activity of a polysaccharide isolated from mori cortex radicis. Arch Pharm Res 23, 240–242 (2000). https://doi.org/10.1007/BF02976452
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DOI: https://doi.org/10.1007/BF02976452