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Synthesis and biological evaluation of phosphonate analogues of 1α, 25-dihydroxyvitamin D3

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  • Medicinal Chemistry & Natural Products
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Abstract

A new series of phosphonate side chain analogues of 1α,25-dihydroxyvitamin D3 (1) have been synthesized. Antiproliferative activities of theses analogues (8a,b and9a,b) using human keratinocyte cell shows that analogues which have natural A-ring show higher activity than unnatural A-ring series and almost equally active to 1α,25-Dihydroxyvitamin D3 (1) at 1 μM level.

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Authors and Affiliations

  1. Department of Chemistry, The Johns Hopkins University, 21218, Baltimore, MD, U.S.A.

    Gyoonhee Han

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  1. Gyoonhee Han
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Correspondence to Gyoonhee Han.

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Han, G. Synthesis and biological evaluation of phosphonate analogues of 1α, 25-dihydroxyvitamin D3 . Arch Pharm Res 23, 206–210 (2000). https://doi.org/10.1007/BF02976446

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  • DOI: https://doi.org/10.1007/BF02976446

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