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Inhibition of aromatase activity by flavonoids


In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 μg/mL), chrysin (IC50: 1.1 μg/mL), and hesperetin (IC50: 1.0 μg/mL).

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Correspondence to John M. Pezzuto.

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Jeong, H.J., Shin, Y.G., Kim, I.H. et al. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 22, 309 (1999).

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Key words

  • Aromatase inhibition
  • Flavonoids
  • Breast cancer