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Inhibition of aromatase activity by flavonoids

Archives of Pharmacal Research volume 22, Article number: 309 (1999) Cite this article

Abstract

In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 μg/mL), chrysin (IC50: 1.1 μg/mL), and hesperetin (IC50: 1.0 μg/mL).

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Author notes

  1. Hyeh -Jean Jeong

    Present address: National Institute of Health, Building 21 Room 136, 20892, Bethesda, MD, USA

Authors and Affiliations

  1. Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, Chicago, IL, USA

    Hyeh -Jean Jeong, Young Geun Shin & John M. Pezzuto

  2. College of Pharmacy, ChungAng University, 156-756, Seoul, Korea

    Il -Hyuk Kim

Authors
  1. Hyeh -Jean Jeong
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  2. Young Geun Shin
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  3. Il -Hyuk Kim
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  4. John M. Pezzuto
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Correspondence to John M. Pezzuto.

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Jeong, H.J., Shin, Y.G., Kim, I.H. et al. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 22, 309 (1999). https://doi.org/10.1007/BF02976369

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  • DOI: https://doi.org/10.1007/BF02976369

Key words

  • Aromatase inhibition
  • Flavonoids
  • Breast cancer