In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 μg/mL), chrysin (IC50: 1.1 μg/mL), and hesperetin (IC50: 1.0 μg/mL).
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Jeong, H.J., Shin, Y.G., Kim, I.H. et al. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 22, 309 (1999). https://doi.org/10.1007/BF02976369
- Aromatase inhibition
- Breast cancer