Skip to main content
Log in

Inhibition of aromatase activity by flavonoids

  • Research Articles
  • Natural Products
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript


In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 μg/mL), chrysin (IC50: 1.1 μg/mL), and hesperetin (IC50: 1.0 μg/mL).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References Cited

  • Brodie, A. M. H. and Njar, V. C. O.: Aromatase inhibitors and breast cancer.Semin. Oncol., 23, 10–20 (1996).

    PubMed  CAS  Google Scholar 

  • Conn, P. M. and Crowley, W. F., Gonadotrophin-releasing hormone and its analogues.N. Engl. J. Med., 324, 93–103 (1991).

    PubMed  CAS  Google Scholar 

  • Harvey, H. A.: Aromatase inhibitors in clinical practice: Current status and a look to the future.Semin. Oncol., 23, Suppl., 9, 33–38 (1996).

    PubMed  CAS  Google Scholar 

  • Hoffman, P. G., Jones, L. A., Kuhn, R. W. and Sitteri, P. K.: Progesterone receptors: saturation analysis by a solid phase hydroxyapatite adsorption technique.Cancer, 46, 2801–2804 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Kellis, J. T. Jr. and Vickery, L. E.: Purification and characterization of human placental aromatase cytochrome P-450,J. Biol. Chem., 262, 4413–4420 (1987).

    PubMed  CAS  Google Scholar 

  • Rabe, T., Rabe, D. and Punnebaum, B.: New aromatase assay and its application for inhibitory studies of aminogluthetimide on microsomes of human term placenta.J. Steroid Biochem., 7, 305–309 (1982).

    Google Scholar 

  • Santen, R. J., Manni, A. and Harvey, H. A.: Endocrine treatment of breast cancer in women.Endocr. Rev., 11, 221–265 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Santen, R. J., Martel, J. and Hoagland, M.: Stromal spindle cells contain aromatase in human breast tumors.J. Clin. Endocrinol. Metab., 79, 627–632 (1994).

    Article  PubMed  CAS  Google Scholar 

  • Siiteri, P. K.: Review of studies on estrogen biosynthesis in the human.Cancer Res., 42, 3269s-3273s (1982).

    PubMed  CAS  Google Scholar 

  • Thompson, E. A. and Siiteri, P. K.: The involvement of human placental microsomal cytochrome P-450 in aromatization.J. Biol. Chem., 249, 5373–5378 (1974a).

    PubMed  CAS  Google Scholar 

  • Thompson, E. A. and Siiteri, P. K.: Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione.J. Biol. Chem., 249, 5364–5372 (1974b).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to John M. Pezzuto.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jeong, H.J., Shin, Y.G., Kim, I.H. et al. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 22, 309–312 (1999).

Download citation

  • Received:

  • Issue Date:

  • DOI:

Key words