Inhibition of aromatase activity by flavonoids

  • Hyeh -Jean Jeong
  • Young Geun Shin
  • Il -Hyuk Kim
  • John M. PezzutoEmail author
Research Articles Natural Products


In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 μg/mL), chrysin (IC50: 1.1 μg/mL), and hesperetin (IC50: 1.0 μg/mL).

Key words

Aromatase inhibition Flavonoids Breast cancer 

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Copyright information

© The Pharmaceutical Society of Korea 1999

Authors and Affiliations

  • Hyeh -Jean Jeong
    • 1
  • Young Geun Shin
    • 1
  • Il -Hyuk Kim
    • 2
  • John M. Pezzuto
    • 1
    Email author
  1. 1.Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of PharmacyUniversity of Illinois at ChicagoChicagoUSA
  2. 2.College of PharmacyChungAng UniversitySeoulKorea

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