Abstract
Two new 1-aryl-2-benzylmercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thiones have been synthesized by known methods (Goerdeleret al., 1967). These triazines on treatment with thiourea as dealkylating agent, in acidic medium afforded the corresponding 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione whch on further reaction with different α, β-unsaturated carbonyl compounds and aryl-cyanamide hydrochloride afforded the related adducts. Some of these compounds show appreciable antithyroidal activity.
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Mehrotra, S., Roychowdhury, P.K., Pandey, K.K. et al. Synthesis of 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione and their latentiation products as antithyroidal agent. Arch. Pharm. Res. 18, 356–360 (1995). https://doi.org/10.1007/BF02976332
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DOI: https://doi.org/10.1007/BF02976332