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Synthesis of 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione and their latentiation products as antithyroidal agent

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Abstract

Two new 1-aryl-2-benzylmercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thiones have been synthesized by known methods (Goerdeleret al., 1967). These triazines on treatment with thiourea as dealkylating agent, in acidic medium afforded the corresponding 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione whch on further reaction with different α, β-unsaturated carbonyl compounds and aryl-cyanamide hydrochloride afforded the related adducts. Some of these compounds show appreciable antithyroidal activity.

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References Cited

  • Astwood, Bissel and Huges.Endocrinology, 37, 465 (1945).

    Article  Google Scholar 

  • Field, L. and Srivastava, P. K.,J. Med. Chem., 16, 428 (1973).

    Article  PubMed  Google Scholar 

  • Gupta, M. B., Mishra, H. D., and srivastava, P. K.,Curr. Sci., 51, 692–95 (1982).

    Google Scholar 

  • Goerdeler, J. and Neuffer, T.,Tetrahedron Lett., 29, 2791 (1967).

    Article  Google Scholar 

  • Goerdeler, J. and Neuffer, T.,Chem. Ber. 104, 1066 (1971).

    Google Scholar 

  • Goerdeler, J. and Neuffer, T.,Chem. Ber. 105, 3138 (1972).

    Article  Google Scholar 

  • Havbottle, R. and Ricahrdson, S.,J. Biochem., 217, 485–91 (1984).

    Google Scholar 

  • Mevigh, I., Field, L., and Hanely, W. S.,J. Med. Chem., 14, 095 (1971).

    Google Scholar 

  • Nichlolas, Z.,Principles of Medicinal Chemistry, Foye, W.O., Ill edition, 603 (1988).

Download references

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Mehrotra, S., Roychowdhury, P.K., Pandey, K.K. et al. Synthesis of 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione and their latentiation products as antithyroidal agent. Arch. Pharm. Res. 18, 356–360 (1995). https://doi.org/10.1007/BF02976332

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  • DOI: https://doi.org/10.1007/BF02976332

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