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Regioselective synthesis of α-L-fucosyl-containing benzyl disaccharides by use of α-L-fucosidases ofAspergillus niger

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Abstract

The activity of fucosidase shows different value depending on disease, eg) fucosidosis and I cell disease are characterized by the absence or deficiences of α-fucosidase, and sera of ovarian cancer patients exhibited a statistically significant deficiency of α-L-fucosidase activity (Zielkeet al., 1972; Kresset al., 1980; Barlowet al., 1981). For the purpose of diagnosis of these disease easily, the manual of test can be developed by preparing kits of hydrophobic-binding substrate of fucosidase that bind C18-column.

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Authors and Affiliations

  1. College of Pharmacy, Kyung Sung University, 110-1 Daeyun-dong, Nam-ku, 608-736, Busan, Korea

    Yong Za Chung, Hong Keun Kwak & Yung Ki Sung

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  1. Yong Za Chung
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  2. Hong Keun Kwak
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  3. Yung Ki Sung
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Chung, Y.Z., Kwak, H.K. & Sung, Y.K. Regioselective synthesis of α-L-fucosyl-containing benzyl disaccharides by use of α-L-fucosidases ofAspergillus niger . Arch. Pharm. Res. 19, 307–311 (1996). https://doi.org/10.1007/BF02976246

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