Abstract
SK-302B, an antibiotic purified from soilStreptomyces sp. 302, was structurally identified as echinomycin (C50H66N11S2). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.
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Kim, S.K., Ahn, C.M., Kim, TU. et al. In Vitro chemosensitivity test of SK-302B on human colon carcinoma cell lines. Arch. Pharm. Res. 19, 261–263 (1996). https://doi.org/10.1007/BF02976237
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DOI: https://doi.org/10.1007/BF02976237