Abstract
A cytotoxic constituent was isolated by bioassay-guided procedure from the roots ofSophora flavescens Aiton (Leguminosae). The constituent was identified as sophoraflavanone G (I) by means of chemical methods and in comparsion with spectral data of standard compound. The ED50 values of constituent I were 0.78, 1.57, 2.14 and 8.59 μg/ml against A549, HeLa, K562 and L1210 cell lines respectively. ConstituentI exhibited highly cytotoxic activities against A 549, K562 and HeLa cells, but showed a mild activity (ED50 value, 5 μg/ml) against L1210 cells. Among the tested cell lines, A549 cells were the most sensitive to constituentI.
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Kim, Y.K., Min, B.S. & Bae, K.H. A cytotoxic constituent fromSophora flavescens . Arch. Pharm. Res. 20, 342–345 (1997). https://doi.org/10.1007/BF02976197
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DOI: https://doi.org/10.1007/BF02976197