Abstract
Six substituted phenacyl derivatives of 4-hydroxypiperidine were prepared and their structures were confirmed through spectroscopic techniques. These newly synthesized derivatives were also screened for analgesic activity by chemical and thermal methods. Only halogenated phenacyl derivatives demonstrated more or less protection against acetic acid induced writhing in mice where as rest of three derivatives were found inactive when screened by this chemical method. Similarly all the six derivatives were proved inactive by tail flick test.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References Cited
Bentley, G. A., Newton, S. H. and Star, J., Studies on the antinociceptive action of α-agonist drugs.Brit. J. Pharmacol., 79, 125–137 (1983).
Distasi, L. C., Costa, M. and Mendacolli, S. L. J., Screening in mice of some medicinal plants used for analgesic purposes in the state of Sao Paulo.J. Ethnopharmacol., 24, 205–211 (1988).
Hameed, S., Saify, Z. S., Baqar Hadi Naqvi, S. M., Saeed, M. Khan, A. and Ahmad, M., Design, synthesis and pharmacological fvaluation of N-methyl-piperidine derivatives.J. Islam. Acad. Sci. Turkey, 5, 245–248 (1992).
Hameed, S., Saify, Z. S., Vaid, F. A., Saeed, M., Khan, A. and Ahmad, M., Synthesis and pharmacological evaluation of N-methylpiperidine analgesics.J. Sci. Islam. R. Iran., 4, 281–284 (1993).
Kugita H, Inove, H., Oine, T. and Hayashi, G., 3-Alkyl-3-phenylpiperidine derivative as analgesics-I.J. Med. Chem., 7, 298–301 (1963).
Kugita, H., Inove, H., Oine, T. and Hayashi, G., 3-Alkyl-3-phenylpiperidine derivative as Analgesics-II.J. Med. Chem., 8, 313–316 (1965).
Mailey, E. A. and Day, A. R., Synthesis of derivatives of alkylated and arylated piperidones and piperidinols.J. Org. Chem., 22, 1061–1065 (1957).
Ong, H. H., Profitt, J. A., Spaulding T. C. and Wilker, J. C., Synthesis and analgesic activity of some spiro (dibenz (b,f) Oxepin-10,4′-Piperidine) derivatives.J. Med. Chem., 22, 834–839 (1979).
Saeed, M., Mansoor, A., Saify, Z. S., Zia, A., Ahmad, V. U. and Iqbal. Z., Synthesis and analgesic activity of 4-piperidinol derivatives.Pak. J. Pharm. Pb. Univ. Lahore., 9, 37–42 (1996).
Turner, R. A. and Hebborn, P.,Screening Methods in Pharmacology, Vol. 1., Academic Press, New York and London, 1971 p. 114.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saeed, M., Saify, Z.S., Iqbal, Z. et al. Synthesis of 4-hydroxypiperidine derivatives and their screening for analgesic activity. Arch. Pharm. Res. 20, 338–341 (1997). https://doi.org/10.1007/BF02976196
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02976196