Abstract
An efficient synthesis of 3-(E)-hydroxy- and 3-(E)-acetoxypropenylcephem derivatives, key intermediates for the synthesis of 3-(E)-propenylcephalosporins was achievedvia Stille coupling reaction of 3-trifloxycephem with 3-(E)-tributylstannylallylic alcohol.
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Lee, Y.S., Lee, J.Y., Jeong, JH. et al. An efficient synthesis of 3-(E)-hydroxypropenyl cephem derivatives, key intermediates for 3-(E)-ammoniopropenylcephalosporin antibiotics. Arch. Pharm. Res. 20, 288–290 (1997). https://doi.org/10.1007/BF02976160
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DOI: https://doi.org/10.1007/BF02976160