Abstract
The enantiomeric composition tests on flurbiprofen and ketoprofen present in patch products and in urine excretions following patch applications were performed as diastereomeric (R)-(+)-1-phenylethylamides by achiral gas chromatography and by gas chromatography-mass spectrometry in selected ion monitoring mode. The method for determination of (R)- and (S)-enantiomers in the range from 0.1 to 5.0 μg was linear (r≥ 0.9996) with acceptable precision (% RSD ≤ 5.2) and accuracy (% RE = 0.6 ~ -2.4). The enantiomeric compositions of flurbiprofen in one patch product and of ketoprofen in five different products were identified to be racemic with relatively good precision (≤ 6.4%). The urinary excretion level of (R)-flurbiprofen was two times higher than its antipode, while the comparable excretion levels of (R)- and (S)-enantiomers for ketoprofen were observed.
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Paik, MJ., Nguyen, DT. & Kim, KR. Enantioseparation of flurbiprofen and ketoprofen in patches and in urine excretions by achiral gas chromatography. Arch Pharm Res 27, 1295–1301 (2004). https://doi.org/10.1007/BF02975897
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DOI: https://doi.org/10.1007/BF02975897