Abstract
Phytochemical investigation of the aqueous extract of the roots of Agrimonia pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activityin vitro, furnished two isocoumarins, agrimonolide (1) and agrimonolide 6-O-β-D-glucoside (3), and (+)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells andtert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC50 values of 88.2 ± 2.8 and 37.7 ± 1.6 μM, respectively.
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Park, EJ., Oh, H., Kang, TH. et al. An isocoumarin with hepatoprotective activity in Hep G2 and primary hepatocytes fromAgrimonia pilosa . Arch Pharm Res 27, 944–946 (2004). https://doi.org/10.1007/BF02975848
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DOI: https://doi.org/10.1007/BF02975848