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Modifier effects on supercritical CO2 extraction efficiency of cephalotaxine fromCephalotaxus wilsoniana leaves

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  • Medicinal Chemistry & Natural Products
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Abstract

The effects of modifiers such as methanol, water, diethylamine in methanol (10 v/v %), and diethylamine in water (10 v/v %) were investigated at three different concentrations (1, 5, and 10 v/v %) of the modifiers in supercritical CO2 (SC-CO2) in order to enhance the supercritical fluid extraction (SFE) efficiency of cephalotaxine fromCephalotaxus wilsoniana leaves. Among the modifiers employed, methanol basified with diethylamine was found to greatly enhance the extraction efficiency relative to any other modifiers employed. The results suggest that cephalotaxine in plant matrices may be readily changed from SC-CO2-insoluble salt to SC-CO2-soluble free base by basified modifiers. In addition, SC-CO2 modified with basified methanol could enhance the extraction efficiency of cephalotaxine more than 30% when compared to the conventional organic solvent extraction.

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Authors and Affiliations

  1. Department of Chemical Engineering, Sogang University, 121-742, Seoul, Korea

    Jin Yeol Kim, Seung Nam Joung & Ki-Pung Yoo

  2. China Medical College, Taichung, Taiwan

    Yuan Shiun Chang

  3. College of Pharmacy, Seoul National University, Shilim-Dong, Kwanak-Gu, San 56-1, 151-742, Seoul, Korea

    Young Hae Choi & Jinwoong Kim

Authors
  1. Young Hae Choi
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  2. Jinwoong Kim
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  3. Jin Yeol Kim
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  4. Seung Nam Joung
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  5. Ki-Pung Yoo
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  6. Yuan Shiun Chang
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Correspondence to Jinwoong Kim.

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Choi, Y.H., Kim, J., Kim, J.Y. et al. Modifier effects on supercritical CO2 extraction efficiency of cephalotaxine fromCephalotaxus wilsoniana leaves. Arch Pharm Res 23, 163–166 (2000). https://doi.org/10.1007/BF02975507

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  • DOI: https://doi.org/10.1007/BF02975507

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