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Cytotoxic peroxides fromArtemisia stolonifera

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  • Medicinal Chemistry & Natural Products
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Abstract

Two sesquiterpene endoperoxides, 1S, 4R, 6R-1, 4-endoperoxy-bisabola-2, 10-diene (I), 1R,4S, 6R-1, 4-endoperoxy-bisabola-2, 10-diene (II), and a sesquiterpene hydroperoxide, 1β-hydroperoxygermacra-4 (15), 5, 10 (14)-triene (III) were isolated from the aerial parts ofArtemisia stolonifera (Compositae). Their chemical structures were assigned by spectral evidences. CompoundsI andII exhibited cytotoxicity against five human tumor cell lines with their ED50 values ranging from 0.20 to 5.43 μg/ml and from <0.1 to 0.87 μg/ml, respectively.

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Authors and Affiliations

  1. Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, 440-746, Suwon, Kyunggi-Do, Korea

    Hak Cheol Kwon & Kang Ro Lee

  2. Korea Research Institute of Chemical Technology, 136-702, Daejeon, Korea

    Sang Un Choi

Authors
  1. Hak Cheol Kwon
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  2. Sang Un Choi
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  3. Kang Ro Lee
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Correspondence to Kang Ro Lee.

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Kwon, H.C., Choi, S.U. & Lee, K.R. Cytotoxic peroxides fromArtemisia stolonifera . Arch Pharm Res 23, 151–154 (2000). https://doi.org/10.1007/BF02975504

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  • DOI: https://doi.org/10.1007/BF02975504

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