Abstract
In continuation of the previous work (Fathalla, 1992) on the synthesis of some heterocycles containing uracil moiety, we report herein the incorporation of uracil moiety into cyanopyridine thione, thiosemecarbazone, semicarbazone, cyanopyridine, aminocyano pyridine, isoxazoline, pyrazoline, pyrimidine, triazolo pyrimidine, pyran, selena and thiazole derivatives which might modify their biological activities.
The biological studies revealed that the chemical compoundIII f showed high molluscicdal activity than other compounds. The profile of the nucleoprotein extracted from chemically (compoundIIIc, e, f andg) treated or UV-irradiatedB. alexandrina snails did not show appreciable differences when compared to non-treated (native) snails by using SDS-PAGE, where no animals with the nucleoprotein extracted from native, chemically (compoundIII f &g) treated or physically treatedB. alexandrina snails induced significant protection against challenge with normalS. mansoni cercariae, as compared to the non-immunized challenged control. As well as, a decrease in the number of granuloma formation and the size range of granuloma was also observed in immunized animals. It is concluded that, compoundsIII f andg have a potent molluscicidal activity. They also induced chemical modification comparable to that induced by physical treatment in the snail’s nucleoprotein, which could possibly be used in immunization againstS. mansoni infection.
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Fathalla, O.A., Gad, H.S.M. & Maghaby, A.S. Synthesis of new uracil-5-sulphonamide-p-phenyl derivatives and their effect onBiomphalaria alexandrina snail’s nucleoproteins. Arch Pharm Res 23, 128–138 (2000). https://doi.org/10.1007/BF02975501
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DOI: https://doi.org/10.1007/BF02975501