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Protection of the flowers ofPrunus persica extract from ultraviolet B-induced damage of normal human keratinocytes

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Abstract

For an attempt to develop safe materials protecting solar ultraviolet (UV)-induced skin damage, plant extracts were evaluated for their inhibitory activities of free radical generation and arachidonic acid/metabolites release from UVB-irradiated normal human keratinocytes. From the results of these screening procedures, the ethanol extract of the flowers ofPrunus persica (Ku-35) was selected for further study. It was found that Ku-35 (100-1,000 μg/ml) inhibited the amount of14C-arachidonic acid/metabolites release from UVB-irradiated keratinocytes. It was also demonstrated that Ku-35 possessed the protective activity against UV-induced cytotoxicity of keratinocytes and fibroblasts. In addition, Ku-35 was revealed to protect UVB-induced erythema formation using guinea pigs in preliminaryin vivo study. All these results indicate that the flowers ofP. persica extract may be beneficial for protecting UV-induced skin damage when topically applied.

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Authors and Affiliations

  1. College of Pharmacy, Kangwon National University, 200-701, Chunchon

    Young Ha Kim, Hye Eun Yang, Moon Young Heo & Hyun Pyo Kim

  2. R & D Center, Coreana Cosmetics Co Ltd., 333-830, Cheonan, Korea

    Jong Ha Kim

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  1. Young Ha Kim
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  2. Hye Eun Yang
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  3. Jong Ha Kim
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  4. Moon Young Heo
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  5. Hyun Pyo Kim
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Correspondence to Hyun Pyo Kim.

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Kim, Y.H., Yang, H.E., Kim, J.H. et al. Protection of the flowers ofPrunus persica extract from ultraviolet B-induced damage of normal human keratinocytes. Arch Pharm Res 23, 396–400 (2000). https://doi.org/10.1007/BF02975454

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  • DOI: https://doi.org/10.1007/BF02975454

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