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Protection of the flowers ofPrunus persica extract from ultraviolet B-induced damage of normal human keratinocytes

Abstract

For an attempt to develop safe materials protecting solar ultraviolet (UV)-induced skin damage, plant extracts were evaluated for their inhibitory activities of free radical generation and arachidonic acid/metabolites release from UVB-irradiated normal human keratinocytes. From the results of these screening procedures, the ethanol extract of the flowers ofPrunus persica (Ku-35) was selected for further study. It was found that Ku-35 (100-1,000 μg/ml) inhibited the amount of14C-arachidonic acid/metabolites release from UVB-irradiated keratinocytes. It was also demonstrated that Ku-35 possessed the protective activity against UV-induced cytotoxicity of keratinocytes and fibroblasts. In addition, Ku-35 was revealed to protect UVB-induced erythema formation using guinea pigs in preliminaryin vivo study. All these results indicate that the flowers ofP. persica extract may be beneficial for protecting UV-induced skin damage when topically applied.

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Correspondence to Hyun Pyo Kim.

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Kim, Y.H., Yang, H.E., Kim, J.H. et al. Protection of the flowers ofPrunus persica extract from ultraviolet B-induced damage of normal human keratinocytes. Arch Pharm Res 23, 396–400 (2000). https://doi.org/10.1007/BF02975454

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Key words

  • UV-induced skin damage
  • Flowers ofPrunus persica (Rosaceae)
  • Human keratinocyte
  • Arachidonic acid
  • Erythema