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Synthesis and antimicrobial activity of some new 2-indolinone derived oximes and spiro-isoxazolines

Archives of Pharmacal Research volume 23, Article number: 310 (2000) Cite this article

Abstract

The synthesis and spectral analysis of some new 1,3-dihydro-3-hydroxy-3-[2-hydroxyimino-2-(substituted phenyl)ethyl]-2H-indol-2-ones (21–32) and spiro[3H-indol-3,5/t’-(4/t’H)-isoxazol]-2(1H)-ones (33–44) are described. Sixteen of the synthesized compounds were screenedin vitro for their growth inhibitory activity against thirteen species of microorganisms,viz, S. aureus, S. epidermidis, S. faecalis, B. subtilis, B. cereus, E. aerogens, E. coli, P. aeruginosa, P. vulgaris, A. baumonia, A. faecalis, C. albicans andS. cervicae. Most of the compounds exhibited significant antimicrobial activity especially the oximes28 and29.

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Affiliations

  1. Department of Microbiology, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt

    Adel A. El-Gendy & Aly M. Ahmedy

  2. Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 11562, Cairo, Egypt

    Adel A. El-Gendy & Aly M. Ahmedy

Authors
  1. Adel A. El-Gendy
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  2. Aly M. Ahmedy
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Correspondence to Adel A. El-Gendy.

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El-Gendy, A.A., Ahmedy, A.M. Synthesis and antimicrobial activity of some new 2-indolinone derived oximes and spiro-isoxazolines. Arch Pharm Res 23, 310 (2000). https://doi.org/10.1007/BF02975439

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  • DOI: https://doi.org/10.1007/BF02975439

Key words

  • Indoline-2,3-dione derivatives
  • Oximes
  • Spiro-isoxazolines
  • Antimicrobial activity