Abstract
Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of 3,23-dihy-droxy-20(29)-lupen-27-oic acid on the regulation of MMP-1 and type 1 procollagen in Ultraviolet irradiation of cultured old age human dermal fibroblasts. 3, 23-dihydroxy-20(29)-lupen-27-oic acid was isolated fromTiarella polyphylla D. Don (Saxifragaceae). Among them, 3, 23-dihydroxy-20(29)-lupen-27-oic acid induced the regulation of Type 1- procollagen and reduced the regulation of MMP-1 at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that 3, 23-dihydroxy-20(29)-lupen-27-oic acid plays an important role in the induction of Type 1-procollagen and reduction of MMP-1 by ultraviolet irradiation in old age human dermal fibroblasts.
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References
Bemhard, E. J., Gruber, S. B., and Muschel, R. J., Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.Proc. Nat. Acad. Sci. U.S.A., 91, 4293–4297 (1994).
Chambers, A. F. and Matrisian, L. M., Changing views of the role of matrix metalloproteinases in metastasis.J. Natl. Cancer Inst., 89, 1260–1270 (1997).
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z. Q., Varani, J., Kang, S., and Voorhees, J. J., Molecular basis of sun- induced premature skin ageing and retinoid antagonism.Nature, 379, 335–339 (1996).
Gilchrest, B. A., Skin aging and photoaging: an overview.J. Am. Acad. Dermatol., 21, 610–613 (1989).
Lee, Y. N. (1996)Flora of Korea, p. 287, Kyo-Hak Publishing Co., Seoul.
Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.J. Immunol. Methods, 65, 55–63 (1983).
Park, S. H., Oh, S. R., Jung, K. Y., Lee, I. S., Ahn, K. S., Kim, J. G., Lee, J. J., and Lee, H. K., Anticomplement activities of oleanolic acid monodesmosides and bisdesmosides isolated fromTiarella polyphylla.Arch. Pharm. Res., 22, 428–431 (1999).
Park, S. H., Oh, S. R., Ahn, K. S., Kim, J. G., and Lee, H. K., Structure determination of a new lupane-type triterpene, tiarellic acid, isolated fromTiarella polyphylla.Arch. Pharm. Res., 25, 57–60 (2002).
Seo, J. Y., Lee, S. H., Youn, C. S., Choi, H. R., Rhie, G. E., Cho, K. H., Kim, K. H., Park, K. C., Eun, H. C., and Chung, J. H., Ultraviolet radiation increases tropoelastin mRNA expression in the epidermis of human skinin vivo.J. Invest. Dermatol., 116, 915–919 (2001).
Varani, J., Warner, R. L., Gharaee-Kermani, M., Phan, S. H., Kang, S., Chung, J. H., Wang, Z. Q., Datta, S. C., Fisher, G. J., and Voorhees, J. J., Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin.J. Invest. Dermatol., 114, 480–486 (2000).
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Moon, H.I., Lee, J., Zee, O.P. et al. Triterpenoid fromTiarella polyphylla, regulation of type 1 procollagen and MMP-1 in ultraviolet irradiation of cultured old age human dermal fibroblasts. Arch Pharm Res 27, 1060–1064 (2004). https://doi.org/10.1007/BF02975432
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DOI: https://doi.org/10.1007/BF02975432