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Protective effect of taurine on TNBS-induced inflammatory bowel disease in rats

Archives of Pharmacal Research volume 21, pages 531–536 (1998)Cite this article

Abstract

We had previously reported that the protective effect of taurine against indomethacin-induced gastric mucosal injury was due to its antioxidant effects, which inhibited lipid peroxidation and neutrophil activation. In this study, we examined the effect of taurine on reducing the inflammatory parameters of trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease (IBD), in rats. In order to induce IBD, ethanolic TNBS was given to rats intracolonically. Then they received 500 mg/kg/day of taurine orally and were sacrificed one week after IBD induction. While ulceration and inflammation of distal colon with formation of granuloma in the vehicle-treated IBD rats two days after administration of TNBS were observed, treatment with taurine ameliorated colonic damage and decreased the incidence of diarrhea and adhesion. Also, colon weight as an index of tissue edema, which was markedly increased in the IBD rats, became significantly lower after taurine treatment. Myeloperoxidase (MPO) activity in the vehicle-treated IBD rats was substantially increased, compared with that of normal control. The taurine-treated animals significantly reduced MPO activity (35% lower) when compared with that of the vehicle-treated animals. Taurine treatment decreased both basal and formyl-methionyl leucyl phenylalanine-stimulated reactive oxygen generation from colonic tissue in the IBD rats. These results suggest that the administration of taurine reduce the inflammatory parameters in this IBD rat model by increasing defending capacity against oxidative damage.

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Affiliations

  1. Research Laboratories of Dong-A Pharmaceutical Co., Ltd., 47-5 Sanggal-Ri Kiheung-Up, 449-900, Yongin-Shi, Kyunggi-Do, Korea

    Mi Won Son, Jun Il Ko, Hyoun Mie Doh & Won Bae Kim

  2. Department of Food and Nutrition, Yonsei University, 120-749, Seoul, Kore

    Tae Sun Park

  3. Department of Life Science, the University of Seoul, 130-743, Seoul, Korea

    Mi Ja Shim

  4. College of Pharmacy, Seoul National University, 151-742, Seoul, Korea

    Byong Kak Kim

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  1. Mi Won Son
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  2. Jun Il Ko
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  3. Hyoun Mie Doh
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  4. Won Bae Kim
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  5. Tae Sun Park
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  6. Mi Ja Shim
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  7. Byong Kak Kim
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Son, M.W., Ko, J.I., Doh, H.M. et al. Protective effect of taurine on TNBS-induced inflammatory bowel disease in rats. Arch. Pharm. Res. 21, 531–536 (1998). https://doi.org/10.1007/BF02975370

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  • DOI: https://doi.org/10.1007/BF02975370

Keywords

  • Taurine
  • Inflammatory bowel disease
  • Trinitrobenzene sulfonic acid
  • Myeloperoxidase
  • Reactive oxygen