Boron trifluoride etherate on silica-A modified lewis acid reagent (VII). Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells

  • Seung Hwa Baek
  • Young Ok Kim
  • Jung Suk Kwag
  • Kyw Eun Choi
  • Woo Young Jung
  • Du Seok Han
Notes

Abstract

Geraniol (1), olivetol (2), cannabinoids (3 and4) and 5-fluorouracil (5) were tested for their growth inhibitory effects against human oral epitheloid carcinoma cell lines (KB) and NIH 3T3 fibroblasts using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.

Key words

Cannabinoid 5-Fluorouracil Cannabigerol Antitumor activity Human oral epitheloid carcinoma cell MTT assay SRB assay 

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Copyright information

© The Pharmaceutical Society of Korea 1998

Authors and Affiliations

  • Seung Hwa Baek
    • 1
  • Young Ok Kim
    • 1
  • Jung Suk Kwag
    • 2
  • Kyw Eun Choi
    • 1
  • Woo Young Jung
    • 3
  • Du Seok Han
    • 3
  1. 1.Department of ChemistryWonkwang UniversityIsanKorea
  2. 2.Department of Dental HygenicMokpo Junior CollegeMokpoKorea
  3. 3.Department of Oral AnatomyWonkwang UniversityIksanKorea

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