Abstract
To explore the effect of substituents on phenyl motif on sulfonyl function of novel anticancer 4-phenyl-1-benzenesulfonylimidazolidinones (1), electron donating or withdrawing substituents were introduced at 3 or 4-position and the analogs were tested agaist human lung (A549) and colon (HCT-15) cancer cell lines. Quantitative structure activity relationship of the 4-substituted series shows that only STERIMOL L values are well correlated. The increment of substituent's volume enhances the activity against both cell lines. The small substituent at 3-position additionally increases the activity. However naphthyl group in place of phenyl reduces the activity. Therefore the phenyl motif with sterically large substituent at 4-position and small substituent at 3-position may be important for their activity. Integration of these substituents' effects into the structural design led to discover the more potent analog, 4-phenyl-1-(N-acetylindoline-5-sulfonyl) imidazolidinone (1n).
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Everitt, E., Wohlfart, C., Spectrometric quantitation of anchorage-dependent cell numbers extraction of naphthol blue-black-stained cellular protein.Anal. Biochem., 162, 122–129 (1987).
Houghton, P. J., Houghton, J. A., Antitumor diarylsulfonylureas: novel agents with unfulfilled promise.Investigational New Drugs, 14, 271–280 (1996).
Howbert, J. J., Sulofenur.Drug of Future, 16, 517–520 (1991) references therein.
Jung, S.-H., Song, J.-S., Lee, H.-S., Choi, S.-U., Lee, C.-O., Synthesis and evaluation of cytotoxicity of novel arylsulfonylimidazolidinones containing sulfonylurea pharmacophore.Arch. Pharm. Res., 19, 570–580 (1996).
Jung, S.-H., Song, J.-S., Lee, H.-S., Choi, S.-U., Lee, C.-O., Synthesis and evaluation of cytotoxic activity of novel arylsulfonylimidazolidinones.Bioorg. & Med. Chem. Letters, 6, 2553–2558 (1996).
Jung, S.-H., Kwak, S.-J., Planar structural requirement at 4-position of 1-arylsulfonyl-4-phenyl-4,5-dihydro-2-imidazolones for their cytotoxicity.Arch. Pharm. Res., 20, 283–287 (1997).
Jung, S.-H., Lee, H.-S., Song, J.-S., Kim, H.-M., Han, S.-B., Lee, C.-W., Lee, M., Choi, D.-R., Lee, J.-A., Chung, Y.-H., Yoon, S.-J., Moon, E.-Y., Hwang, H.-S., Seong, S.-K., Lee, D.-K., Synthesis and antitumor activity of 4-phenyl-1-arylsulfonylimidazolidinones.Bioorg. & Med. Chem. Letters, 8, 2553–2558 (1997).
Perrin, D. D., Armarego, W. L. F., and Perrin, D. R.,Purification of laboratory chemicals, 2nd edition. Pergamon Press, Oxford, England, 1982.
Skehan, P., Storeng, R., Scudiero, D. A., Monks, A., MacMahon, J., Vista, D. T., Kenny, S., Boyd, M. R. New colorimetric cytotoxicity assay for anticancer drug screening.J. Natl. Cancer Inst., 82, 1107–1112 (1990).
Skagerberg, B., Bonelli, D., Clementi, S., Cruciani, G., Ebert, C.,Quantitative Structure Activity Relationship, 8, 32–38 (1989).
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Lee, HS., Park, KL., Choi, SU. et al. Effect of substituents on benzenesulfonyl motif of 4-phenyl-1-arylsulfonylimidazolidinones for their cytotoxicity. Arch Pharm Res 23, 579–584 (2000). https://doi.org/10.1007/BF02975244
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DOI: https://doi.org/10.1007/BF02975244