Abstract
Phytochemical investigation of the MeOH extract of the root barks ofCudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activityin vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds1, 2, and4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Amit, G., Cohen, P., and Ackerman, Z., Nitrofurantoin-induced chronic active hepatitis.Isr. Med. Assoc. J., 4, 184–186 (2002).
Edoute, Y., Karmon, Y., Roguin, A., and Ben-Ami, H., Fatal liver necrosis associated with the use of nitrofurantoin.Isr. Med. Assoc. J., 3, 382–383 (2001).
Grant, M. H., Duthie, S. J., Gray, A. G., and Bruke, M. D., Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line.Biochem. Pharmacol., 37, 4111–4116 (1988).
Groweiss, A., Cardellina, J. H., and Boyd, M. R., HIV-inhibitory prenylated xanthones and flavones fromMadura tinctoria.J. Nat. Prod., 63, 1537–1539 (2000).
Hano, Y., Matsumoto, Y., Shinohara, K., Sun, J. Y., and Nomura, T., Structures of four isoprenylated xanthones, cudraxanthones L, M, N, and O fromCudrania tricuspidata., 57, 172–175 (1991).
Jiang su New Medical College. Encyclopedia of Chinese medicinal substances. Shanghai Peoples Publisher, Shanghai, p. 1502 (1977).
Kelly, B. D., Heneghan, M. A., Bennani, F., Connolly, C. E., and O’Gorman T. A., Nitrofurantoin-induced hepatotoxicity mediated by CD8+T cells.Am. J. Gastroenterol., 93, 819–821 (1998).
Klee, S., Numberger, M. C., and Ungemach, F. R., The consequences of nitrofurantoin-induced oxidative stress in isolated rat hepatocytes: evaluation of pathobiochemical alterations.Chem. Biol. Interact, 93, 91–102 (1994).
Osseni, R. A., Debbasch, C., Christen, M. O., Rat, P., and Warnet, J. M., Tacrine-induced reactive oxygen species in a human liver cell line: the role of anethole dithiolethione as a scavenger.Toxicol. In Vitro, 13, 683–688 (1999).
Song, E. K., Cho, H., Kim, J.S., Kim, N.Y., An, N. H., Kim, J. A., Lee, S. H., and Kim, Y.C., Diarylheptanoids with free radical scavenging and hepatoprotective activityin vitro fromCurcuma longa.Planta Med., 67, 876–877 (2001).
Watkins, P. B., Zimmerman, H. J., Knapp, M. J., Gracon, S. I., and Lewis, K. W., Hepatotoxic effects of tacrine administration in patients with Alzheimers disease.J. Am. Med. Assoc., 271, 992–998 (1994).
Zou, Y. S., Hou, A. J., Zhu, G. F., Chen, Y. F., Sun, H. D., and Zhao, Q. S., Cytotoxic isoprenylated xanthones fromCudrania tricuspidata.Bioorg. Med. Chem., 12, 1947–1953 (2004).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tian, YH., Kim, HC., Cui, JM. et al. Hepatoprotective constituents ofcudrania tricuspidata . Arch Pharm Res 28, 44–48 (2005). https://doi.org/10.1007/BF02975134
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02975134