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Prolyl Endopeptidase inhibitors from green tea

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  • Medicinal Chemistry & Natural Products
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Abstract

Three prolyl endopeptidase (PEP) inhibitors were isolated from the methanolic extract of green tea leaves. They were identified as (-)-epigallocatechin gallate, (-)-epicatechin gallate, and (+)-gallocatechin gallate with the IC50 values of 1.42 × 10-4 mM, 1.02 × 10-2 mM, and 1.09 × 10-4 mM, respectively. They were non-competitive with a substrate in Dixon plots and did not show any significant effects against other serine proteases such as elastase, trypsin, and chymotrypsin, suggesting that they were relatively specific inhibitors against PEP. The isolated compounds are expected to be useful for preventing and curing of Alzheimer’s disease.

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  1. Dept. of Agricultural Chemistry, College of Agriculture, Kyungpook National University, 1370, Sankyuk-Dong, 702-701, Taegu, Korea

    Jin-Hui Kim, Sang-In Kim & Kyung-Sik Song

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  1. Jin-Hui Kim
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  2. Sang-In Kim
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  3. Kyung-Sik Song
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Correspondence to Kyung-Sik Song.

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Kim, JH., Kim, SI. & Song, KS. Prolyl Endopeptidase inhibitors from green tea. Arch Pharm Res 24, 292–296 (2001). https://doi.org/10.1007/BF02975094

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  • DOI: https://doi.org/10.1007/BF02975094

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