Gene expression of novel retro virus associated with human acute muloid leukemia
- 12 Downloads
Objective: To explore the potentiality of retroviral etiology in human acute myeloid leukemia(AML). Methods: The expression of clone 6#11 in leukemic cell samples from 19 AML cases and peripheral blood mononuclear cells (PBMNCs) from 20 controls was studied by means of Northern blot and reversal transcription polymerase chain reaction (RT-PCR). Results: Northern blot and RT-PCR analyses showed that the expression level of clone 6#11 was significantly higher in AML patients than that in control. Conclusion: Northern blot and RT-PCR analyses revealed that the expression of novel retrovirus were associated with acute myeloid leukemia.
Key wordsGene expression Retrovirus Acute myeloid leukemia
Unable to display preview. Download preview PDF.
- Bennett D, Catoyskv D, Daniel MT, et al. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group[J]. Ann Intern Med 1985; 103: 629–33.Google Scholar
- Mecatonia SE, Lan K, Dotterson S, et al. Dendritic cell infection, depletion and dysfunction in HIV-infected individuals [J]. Immunology 1990; 71: 38–45.Google Scholar