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Chinese Journal of Cancer Research

, Volume 15, Issue 2, pp 98–101 | Cite as

Gene expression of novel retro virus associated with human acute muloid leukemia

  • Xu Xiao-hua 
  • Xu Rong-zhen 
  • Wang Shi-jiong 
  • Zheng Shu 
  • Zhu Ning-xi 
  • Zhou Xuan 
Article
  • 13 Downloads

Abstract

Objective: To explore the potentiality of retroviral etiology in human acute myeloid leukemia(AML). Methods: The expression of clone 6#11 in leukemic cell samples from 19 AML cases and peripheral blood mononuclear cells (PBMNCs) from 20 controls was studied by means of Northern blot and reversal transcription polymerase chain reaction (RT-PCR). Results: Northern blot and RT-PCR analyses showed that the expression level of clone 6#11 was significantly higher in AML patients than that in control. Conclusion: Northern blot and RT-PCR analyses revealed that the expression of novel retrovirus were associated with acute myeloid leukemia.

Key words

Gene expression Retrovirus Acute myeloid leukemia 

CLC number

R733.71 

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Copyright information

© Chinese Journal of Cancer Research 2003

Authors and Affiliations

  • Xu Xiao-hua 
    • 1
  • Xu Rong-zhen 
    • 1
  • Wang Shi-jiong 
    • 1
  • Zheng Shu 
    • 2
  • Zhu Ning-xi 
    • 2
  • Zhou Xuan 
  1. 1.Department of Hematology, The Second Affiliated HospitalZhejiang University Medical CollegeHangzhou
  2. 2.Cancer InstituteZhejiang UniversityHangzhou

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