Abstract
In order to study the relationship of p53 gene mutation with the occurrence and prognosis of cancer of small intestine, expression of p53 protein was immunohistochemically examined. The results showed that p53 protein expression was high in 75% of small intestine cancer, and positive in 21.1% of the tissues close to cancer. In 7 cases of small intestinal adenoma, only one was immunoreactive. Sixteen samples of normal tissue of the intestine didn’t show expression of p53 protein. The study also found that the degree of p53 protein expression was significantly correlated with that of tumor cell differentiation, invasion, metastasis and prognosis.
Similar content being viewed by others
References
Leving AJ. The p53 tumor suppressor gene and products. Cancer Surv 1992; 12:59.
Van den Berg FM, Tigges AJ, Schipper ME, et al. Expression of the nuclear oncogene p53 in colon tumors. Pathology 1989; 157:193.
Kern SE, Fearon ER, Tersmette KW, et al. Clinical and pathological associations with allelic loss in colorectal carcinoma. JAMA 1989; 261:3099.
Iino H, Fukayama M, Maeda Y, et al. Molecular genetics for clinical management of colorectal carcinoma: 17p, 18q and 22q loss of heterozygosity and decreased DCC expression are correlated with the matastatic potential. Cancer 1994; 73:1324.
Kikuchi-Yanoshita R, Konishi M, Ito S, et al. Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and nonfamilial adenomatous polyposis patients. Cancer Res 1992; 52:3965.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ge, C., He, S., Tian, Y. et al. Expression of p53 protein in cancers of small intestine and its relationship to clinical course and prognosis. Chin J Cancer Res 9, 49–52 (1997). https://doi.org/10.1007/BF02974722
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02974722