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Yomogin, an inhibitor of nitric oxide production in LPS-activated macrophages

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In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plantArtemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.

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References Cited

  • Bredt, D. S. and Snyder, S. H., Isolation of nitric oxide synthase, a calmodulin-requiring enzyme.Proc. Natl. Acad. Sci. USA, 87, 682–685 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Brouet, I. and Oshima, H., Curcumin, an anti-tumor promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages.Biochem. Biophys. Res. Commun., 206, 533–540 (1995).

    Article  PubMed  CAS  Google Scholar 

  • Forstermann, U., Schmidt, H. H., Pollock, J. S., Sheng, H., Mitchell, J. A., Warner, T. D., Nakaue, M. and Murad, F., Isoforms of nitric oxide synthase. Characterization and purification from different cell types.Biochem. Pharmacol., 42, 1849–1857 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Green, L. C., Wagner, D. A., Glogowski, J., Skipper, P. L., Wishnok, J. S. and Tannenbaum, S. R., Analysis of nitrate, nitrite and [15N] nitrate in biological fluids.Anal. Biochem., 126, 131–138 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Iida, S., Oshima, H., Oguchi S., Hata, T., Suzuki, H., Kawazaki, H., Esumi, H., Identification of inducible calmodulin-dependent nitric oxide synthase in the liver of rats.J. Biol. Chem., 267, 25385–25388 (1992).

    PubMed  CAS  Google Scholar 

  • Jakupovic, J., Schuster, F., Bohlmann, F. and Dillon, M. O., Lumiyomogin, ferreyrantholide, fruticolide and other sesquiterpene lactones fromFerreyranthus fruticosus.Phytochemistry, 27, 1113–1120 (1988).

    Article  CAS  Google Scholar 

  • Kilbourn, R. G. and Belloni, P., Endothelial cell production of nitrogen oxides in response to interferon γ in combination with tumor necrosis factor, interleukin-1, or endotoxin.J. Natl. Cancer Inst., 82, 772–776 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Kilbourn, R. G., Gross, S. S., Jubran, A., Adams, J., Griffith, O. W., Levi, R. and Lodato, R. F., NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implication for the involvement of nitric oxide.Proc. Natl. Acad. Sci. USA, 87, 3629–3632 (1990)

    Article  PubMed  CAS  Google Scholar 

  • Kondo, Y., Yakano, F. and Hojo, H., Inhibitory effect of bisbenzylisoquinoline alkaloids on nitric oxide production in activated macrophages.Biochem. Pharmacol., 46, 1887–1892 (1993).

    Article  PubMed  CAS  Google Scholar 

  • Niwa, M., Nakamura, N., Kitajima, K., Ueda, M., Tsutsumishita, Y., Futaki, S. and Takaishi, Y., Benzoquinones inhibit the expression of inducible nitric oxide synthase gene.Biochem. Biophys. Res. Commun., 239, 367–371 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Oshima, H. and Bartsch, H., Chronic infectious and inflammation process as cancer risk factors: possible role of nitric oxide in carcinogenesis.Mutat. Res., 305, 253–264 (1994).

    Google Scholar 

  • Park, H.-J., Jung, W.-T., Basnet, P., Kadota, S. and Namba, T., Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark ofMagnolia sieboldii.J. Nat. Prod., 59, 1128–1130 (1996).

    Article  PubMed  CAS  Google Scholar 

  • Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. and Nathan, C. F., Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.Proc. Natl. Acad. Sci. USA, 88, 7773–7777 (1991).

    Article  PubMed  CAS  Google Scholar 

  • Thiemermann, C. and Vane, J., Inhibition of nitrix oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the ratin vivo.Eur. J. Pharmacol., 182, 591–595 (1990).

    Article  PubMed  CAS  Google Scholar 

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Ryu, JH., Lee, H.J., Jeong, Y.S. et al. Yomogin, an inhibitor of nitric oxide production in LPS-activated macrophages. Arch. Pharm. Res. 21, 481–484 (1998).

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