Abstract
In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plantArtemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.
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Ryu, JH., Lee, H.J., Jeong, Y.S. et al. Yomogin, an inhibitor of nitric oxide production in LPS-activated macrophages. Arch. Pharm. Res. 21, 481–484 (1998). https://doi.org/10.1007/BF02974648
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DOI: https://doi.org/10.1007/BF02974648