Studies of structure activity relationship of flavonoids for the anti-allergic actions
The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 μM.
Key wordsAllergy Flavonoids Degranulation Hexosaminidase
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- Fischer, M. J., Paulussen, J. J., Horbach, D. A., Roelofsen, E. P., van Miltenburg, J. C., de Mol, N. J. and Janssen, L. H., Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects.Inflamm. Res, 44, 92–97 (1995).PubMedCrossRefGoogle Scholar
- Kim, C. J. and Chung, J. M., Pharmacological activites of flavonoids (I)-relationship of chemical structure of flavonoids and their inhibitory activity of hypersensitivities.Yakhak Hoeji, 34, 348–364 (1990).Google Scholar