Ethanolic extract ofDaucus carota (DC) at the dose of 10–100 mg/kg caused a dose-dependent fall in systolic and diastolic arterial, blood pressure in normotensive anesthetized rats. These effects were not blocked by atropine (1 mg/kg) and pretreatment withDC did not alter the pressor response to norepinephrine indicating that, cardiovascular effects ofDC are independent of cholinergic or adrenergic receptors involvement. In spontaneously beating guinea-pig paired atria,DC induced a, concentration-dependent (0.3–5 mg/ml) decrease in force and rate of atrial contractions. In rabbit thoracic aorta,DC caused inhibition of K+-induced contractions at similar concentrations. These results suggest that the extract may exhibit Ca2+ channel blocking-like direct relaxant action on cardiac and smooth muscle preparations and this action may be responsible for its hypotensive effect observed in thein vivo studies.
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Gilani, A.H., Shaheen, F. & Saeed, S.A. Cardiovascular actions ofDaucus carota . Arch. Pharm. Res. 17, 150–153 (1994). https://doi.org/10.1007/BF02974250
- Daucus carota
- In vivo
- In vitro