Abstract
The antimutagenic effects of 27 kinds of plant flavonoids on the mutagenicity of aflatoxin B1(AFB1) and N-methyl-N′-nitro-N-nitrosoguanidine(MNNG) inSalmonella typhimurium TA100 were investigated. In the mixed applications of AFB1 (1 μg/plate) with the flavonoids (300 μg/plate) in the presence of a mammalian metabolic activation system (S9 mix), chrysin, apigenin, luteolin and its glucoside, kaempferol, fisetin, morin, naringenin, hesperetin, persicogenin, (+)-catechin and (−)-epicatechin showed the antimutagenic effect against AFB1 with more than 70% inhibition rate. A little or no antimutagenicities except flavone against MNNG (0.5 μg/plate) were observed. For the antimutagenicity of the flavonoids on AFB1, the flavonoid structure that contains the free 5-, 7-hydroxyl group seemed to be essential. However, saturation of the 2,3-double bond or elimination of the 4-keto group did not affect the activity.
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Choi, J.S., Park, K.Y., Moon, S.H. et al. Antimutagenic effect of plant flavonoids in theSalmonella assay system. Arch. Pharm. Res. 17, 71–75 (1994). https://doi.org/10.1007/BF02974226
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DOI: https://doi.org/10.1007/BF02974226