Abstract
A series of 12 pyrimidine derivatives were prepared and tested in vitro against growth, sporulation and nucleic acids ofFusarium oxysporum f. sp.lycopersici andHelminthosporium oryzae. Introduction of thiazole ring together with two aryl groups to 2-aminopyrimidine induced drastic toxicity for both fungi. Pyrimidine derivatives with aryl groups were less toxic. Nitro groups were found to enhance the toxicity of the pyrimidine derivatives especially when substituted in ortho-position of the aryl groups. Inhibition of nucleic acids synthesis of both fungi was attributed mainly to the presence of thiazole ring.
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Ouf, S.A., Sherif, S.M. Synthesis and fungitoxicity of some pyrimidine derivatives. Arch. Pharm. Res. 16, 62–67 (1993). https://doi.org/10.1007/BF02974130
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DOI: https://doi.org/10.1007/BF02974130